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Secretin receptor family
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Secretin receptor family : ウィキペディア英語版
Secretin receptor family

Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.
This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GPCR). Many secretin receptors are regulated by peptide hormones from the glucagon hormone family.
The secretin-receptor family GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have 7 transmembrane helices,〔; 〕 like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature.
The secretin-receptor family GPCRs exist in many animal species, but have not been found in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized.
== Subfamily B1 ==
Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.
* Pituitary adenylate cyclase-activating polypeptide type 1 receptor
*
* PACAPR (ADCYAP1R1)
* Calcitonin receptor
*
* CALCR
* Corticotropin-releasing hormone receptor
*
* CRHR1; CRHR2
* Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor
*
* GIPR
* Glucagon receptor
*
* GCGR
* Glucagon receptor-related
*
* GLP1R; GLP2R;
* Growth hormone releasing hormone receptor
*
* GHRHR
* Parathyroid hormone receptor
*
* PTHR1; PTHR2
* Secretin receptor
*
* SCTR
* Vasoactive intestinal peptide receptor
*
* VIPR1; VIPR2

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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